Preheat the oven to 425°F (220°C) and line a baking sheet with parchment paper.
Pat the chicken tenders dry with paper towels.
In one shallow bowl, whisk together the egg and milk.
In another bowl, combine the panko breadcrumbs, Parmesan cheese, garlic powder, onion powder, Italian seasoning, paprika, salt, and black pepper.
Lightly coat the chicken tenders with olive oil.
Dip each tender into the egg mixture, then press it into the Parmesan breadcrumb mixture until evenly coated.
Arrange the coated chicken tenders on the prepared baking sheet in a single layer.
Lightly spray the tops with cooking spray.
Bake for 18 to 20 minutes, flipping halfway through, until golden brown and the internal temperature reaches 165°F (74°C).
Let the chicken rest for 5 minutes before serving.
Garnish with chopped parsley and serve with lemon wedges if desired.